Acute Myelogenous Leukemia - A Medical Dictionary, by Icon Health Publications

By Icon Health Publications

This can be a 3-in-1 reference e-book. It offers a whole scientific dictionary overlaying enormous quantities of phrases and expressions with regards to acute myelogenous leukemia. It additionally supplies huge lists of bibliographic citations. eventually, it presents info to clients on tips on how to replace their wisdom utilizing numerous net assets. The e-book is designed for physicians, clinical scholars getting ready for Board examinations, scientific researchers, and sufferers who are looking to get to grips with examine devoted to acute myelogenous leukemia. in the event that your time is effective, this ebook is for you. First, you won't waste time looking out the web whereas lacking loads of suitable info. moment, the booklet additionally saves you time indexing and defining entries. eventually, you won't waste money and time printing countless numbers of web content.

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Extra resources for Acute Myelogenous Leukemia - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References

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Determine how mutations in the Runx1 Runt domain found in FPD/AML and M-0, AML patients affect DNA-binding, CBFP heterodimerization, and the Runt domain structure. 2. Determine whether point mutations in the Runx1 Runt domain found in FPD/AML patients result in haploinsufficiency, in the generation of partially functional Runx1 alleles, or in transdominant negative Runx1 alleles. 3. Generate and characterize mouse models for FPD/AML that mimic the hematopoietic progenitor defects, platelet defects, and propensity for AML.

It is likely that this approach will reveal clusters of genes which will re-define subclasses of childhood AML. (2) Prognostic significance of genes involved in drug resistance and apoptotic pathways. Modulation of drug resistance by high dose cyclosporine and high dose cytarabine were the two therapeutic questions addressed by #9421, resulting in 4 study cohorts. Although early in follow-up, there is a trend to increased survival with high dose cyclosporine. Drug transporters and other genes known to be involved in therapeutic responses will be examined for prognostic importance in each treatment cohort.

If the immunotherapeutic and pharmacologic approaches demonstrate biologic activity and safety, we plan to evaluate them in combination as well. The specific aims of this project are: 1. To determine the safety and biologic activity of vaccination with MAIAP in patients with AML. 2. To identify novel AML antigens through antibodybased expression cloning strategies. 3. To determine the toxicity and biologic activity of novel flt3 inhibitors in patients with AML. ; Associate Professor; Mayo Clinic Coll of Medicine, Rochester 200 1St St Sw Rochester, Mn 55905 Timing: Fiscal Year 2002; Project Start 01-APR-1998; Project End 31-JAN-2003 Summary: (adapted from the investigator's abstract) The t(7;11) in patients with acute myeloid leukemia (AML) generates a fusion gene encoding the amino-terminal NUP98, an FG repeat-containing nuclear pore complex protein (NPC), and the carboxy-terminus of HOXA9, a homeotic transcription factor.

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